Dr. Richard G. Frank, from Harvard Medical School, explores a variety of promising early childhood interventions that aim to prevent ill health, substance use disorders, and other social problems. A recurring challenge to policy makers is how to identify and foster promising innovations in early childhood programming. Dr. Frank examines issues related to identifying innovations that work and can be brought to scale in the context of social policy. He offers a framework for identifying what works and is likely to be scalable, we and addresses issues related to the cost-effectiveness of early intervention and prevention programs.