Highlighting key speeches from the 2010 Recovery from Addiction: A Science in Action Symposium, this summary video records major speaking points centred on the following topics: the neuroscience of addiction and the reward system; the clinical implications of the science; the applicability of the chronic disease management model to addiction treatment; and quality improvement strategies, evaluation, and performance for treatment delivery. The symposium established two core anchoring principles: first, that early experiences lay the foundation for healthy brain development and all aspects of human development across the lifespan; and second, that addiction is a chronic disease of brain reward and motivational systems, with its roots in toxic stressful experiences.